HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia methanol dichloromethane → 3-(2,4-dichlorophenyl)propynoic acid-[3-methoxy-4-(2-diethylaminoethoxy)phenyl]amide Hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia methanol dichloromethane | HCID 21584172 | — |
| Reactant | 4-(2-Diethylaminoethoxy)-3-methoxyphenylamine | HCID 22496134 | — |
| Reactant | (2,4-dichlorophenyl)propynoic Acid Chloride | HCID 87587808 | — |
| Product | 3-(2,4-dichlorophenyl)propynoic acid-[3-methoxy-4-(2-diethylaminoethoxy)phenyl]amide Hydrochloride | HCID 68819202 | — |
Reaction Steps
Prepared analogously to Example 2.3.f. from (2,4-dichlorophenyl)propynoic acid chloride and [2-(2-methoxy-4-aminophenoxy)ethyl]diethylamine. Yield: 0.25 g (31.2% of theory); melting point: 205° C.-207° C.; C22H24Cl2N2O3*HCl (M=471.81); calc.: molecular ion peak (M+H)+: 435/437/439; found: molecular ion peak (M+H)+: 435/437/439; Rf value: 0.6 (silica gel, dichloromethane/methanol/ammonia (50:10:0.1)).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07592373B2 |
| Source dataset | uspto-grants-2009_09 |
| ORD ID | ord-0fa7e9cee5274d399cf7a2ecf6a16e81 |
| Source note | uspto-grants-2009_09 |