HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-nitro-1-(2-pyrrolidin-1-ylethyl)-1H-indole → 5-Amino-1-(2-pyrrolidin-1-ylethyl)indole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-nitro-1-(2-pyrrolidin-1-ylethyl)-1H-indole | HCID 11402695 | — |
| Reactant | Ammonia methanol dichloromethane | HCID 21584172 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 5-Amino-1-(2-pyrrolidin-1-ylethyl)indole | HCID 11390574 | — |
Reaction Steps
Prepared analogously to Example 3.1.b. from 5-nitro-1-(2-pyrrolidin-1-ylethyl)-1H-indole in THF as solvent. Yield: 0.83 g (93.9% of theory); C14H19N3 (M=229.32); calc.: molecular ion peak (M+H)+: 230; found: molecular ion peak (M+H)+: 230; Rf value: 0.37 (silica gel, dichloromethane/methanol/ammonia (90:10:1)).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07592373B2 |
| Source dataset | uspto-grants-2009_09 |
| ORD ID | ord-1da1b1f0da7f46d491af079431fed131 |
| Source note | uspto-grants-2009_09 |