2-[(Pyrrolidin-1-yl)methyl]-1,3-benzoxazol-5-amine → 3-(2-chloro-4-trifluoromethylphenyl)propynoic Acid (2-pyrrolidin-1-ylmethylbenzoxazol-5-yl)amide

Participants

Reaction Steps

Prepared analogously to Example 2.3.f. from 0.2 g (0.92 mmol) of 2-pyrrolidin-1-ylmethylbenzoxazol-5-ylamine and 0.2 g (0.8 mmol) of (2-chloro-4-trifluoromethylphenyl)propynoic acid. Yield: 290 mg (81% of theory); C22H17ClF3N3O2 (M=447.84); melting point: 218° C.-223° C.; calc.: molecular ion peak (M+H)+: 448/450 (Cl); found: molecular ion peak (M+H)+: 448/450 (Cl); Rf value: 0.33 (silica gel, dichloromethane/methanol (19:1)).

Provenance & Evidence