4-(2-Diethylaminoethoxy)-3-methoxyphenylamine → 3-(2-chloro-4-trifluoromethylphenyl)propynoic acid-[3-methoxy-4-(2-diethylaminoethoxy)phenyl]amide Hydrochloride

Participants

Reaction Steps

Prepared analogously to Example 2.3.f. from 75 mg (0.30 mmol) of (2-chloro-4-trifluoromethylphenyl)propynoic acid and 79 mg (0.33 mmol) of [2-(2-methoxy-4-aminophenoxy)ethyl]diethylamine. Yield: 14 mg (10% of theory); C23H24ClF3N2O3 (M=468.90); calc.: molecular ion peak (M+H)+: 469/471; found: molecular ion peak (M+H)+: 469/471; Rf value: 0.35 (silica gel, dichloromethane/methanol (9:1)).

Provenance & Evidence