HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(2-Chloro-4-nitrobenzyl)piperidine → 3-Chloro-4-piperidin-1-ylmethylphenylamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(2-Chloro-4-nitrobenzyl)piperidine | HCID 68819343 | — |
| Solvent | Dichloromethane methanol | HCID 21226129 | — |
| Product | 3-Chloro-4-piperidin-1-ylmethylphenylamine | HCID 28721833 | — |
Reaction Steps
Prepared analogously to Example 3.1.b. from 1-(2-chloro-4-nitrobenzyl)piperidine. Yield: 1.88 g (90% of theory); C12H17ClN2 (M=224.73); calc.: molecular ion peak (M+H)+: 225/227 (Cl); found: molecular ion peak (M+H)+: 225/227 (Cl); Rf value: 0.2 (silica gel, dichloromethane/methanol (9:1)).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07592373B2 |
| Source dataset | uspto-grants-2009_09 |
| ORD ID | ord-55380d93e64c4226823cf4365f85583b |
| Source note | uspto-grants-2009_09 |