HuagongsheHuagongshe Chemistry Print Report · For research reference only
(2-Chloro-4-trifluoromethylphenyl)propynoic acid → 3-(2-Chloro-4-trifluoromethylphenyl)propynoic acid-{3-methoxy-4-[2-(4-methylpiperidin-1-yl)ethoxy]phenyl}amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (2-Chloro-4-trifluoromethylphenyl)propynoic acid | HCID 68817422 | — |
| Reactant | 3-Methoxy-4-[2-(4-methylpiperidin-1-yl)ethoxy]phenylamine | HCID 68819112 | — |
| Solvent | Dichloromethane methanol | HCID 21226129 | — |
| Product | 3-(2-Chloro-4-trifluoromethylphenyl)propynoic acid-{3-methoxy-4-[2-(4-methylpiperidin-1-yl)ethoxy]phenyl}amide | HCID 57845683 | — |
Reaction Steps
Prepared analogously to Example 2.3.f. from (2-chloro-4-trifluoromethylphenyl)propynoic acid and 3-methoxy-4-[2-(4-methylpiperidin-1-yl)ethoxy]phenylamine. Yield: 70 mg (23.5% of theory); melting point: 207° C.-209° C.; C25H26ClF3N2O3 (M=494.94); calc.: molecular ion peak (M+H)+: 495/497; found: molecular ion peak (M+H)+: 495/497; Rf value: 0.45 (silica gel, dichloromethane/methanol (9:1)).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07592373B2 |
| Source dataset | uspto-grants-2009_09 |
| ORD ID | ord-51d1377933aa4e09ab36bdcd82c687e5 |
| Source note | uspto-grants-2009_09 |