HuagongsheHuagongshe Chemistry Print Report · For research reference only
(2-Chloro-4-trifluoromethylphenyl)propynoic acid → HCID 57845818, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (2-Chloro-4-trifluoromethylphenyl)propynoic acid | HCID 68817422 | — |
| Reactant | HCID 68817651 | HCID 68817651 | — |
| Solvent | Dichloromethane methanol | HCID 21226129 | — |
| Product | HCID 57845818 | HCID 57845818 | — |
Reaction Steps
Prepared analogously to Example 2.3.f. from (2-chloro-4-trifluoromethylphenyl)propynoic acid and {(S)-1-[2-(4-amino-2-methoxyphenoxy)ethyl]pyrrolidin-2-yl}methanol. Yield: 140 mg (58.9% of theory); melting point: decomposition at 300° C.; C24H24ClF3N2O4 (M=496.91); calc.: molecular ion peak (M+H)+: 497/499; found: molecular ion peak (M+H)+: 497/499; Rf value: 0.2 (silica gel, dichloromethane/methanol (9:1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07592373B2 |
| Source dataset | uspto-grants-2009_09 |
| ORD ID | ord-6e9b82b67a504e67805836a2979bdace |
| Source note | uspto-grants-2009_09 |