HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Methoxy-1-[2-(2-methoxy-4-nitrophenoxy)ethyl]piperidine → 3-Methoxy-4-[2-(4-methoxypiperidin-1-yl)ethoxy]phenylamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Methoxy-1-[2-(2-methoxy-4-nitrophenoxy)ethyl]piperidine | HCID 68817400 | — |
| Solvent | Dichloromethane methanol | HCID 21226129 | — |
| Product | 3-Methoxy-4-[2-(4-methoxypiperidin-1-yl)ethoxy]phenylamine | HCID 68815864 | — |
Reaction Steps
Prepared analogously to Example 3.1.b. from 1 g (3.22 mmol) of 4-methoxy-1-[2-(2-methoxy-4-nitrophenoxy)ethyl]piperidine. Yield: 0.85 g (94% of theory); C15H24N2O3 (M=280.36); calc.: molecular ion peak (M+H)+: 281; found: molecular ion peak (M+H)+: 281; Rf value: 0.6 (silica gel, dichloromethane/methanol (9:1)).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07592373B2 |
| Source dataset | uspto-grants-2009_09 |
| ORD ID | ord-c06d88dda25e4524b65cc74c9b471759 |
| Source note | uspto-grants-2009_09 |