4-[2-(3,4-dihydro-1H-isoquinolin-2-yl)ethoxy]-3-methoxyphenylamine → 3-(2-chloro-4-trifluoromethylphenyl)propynoic acid-{4-[2-(3,4-dihydro-1H-isoquinolin-2-yl)ethoxy]-3-methoxyphenyl}amide formate

Participants

Reaction Steps

Prepared analogously to Example 2.3.f. from 150 mg (0.6 mmol) of (2-chloro-4-trifluoromethylphenyl)propynoic acid and 304 mg (0.66 mmol) of 4-[2-(3,4-dihydro-1H-isoquinolin-2-yl)ethoxy]-3-methoxyphenylamine (65%). Yield: 17 mg (5% of theory); melting point: 92° C.-95° C.; C28H24ClF3N2O3 (M=528.96)*CH2O2; calc.: molecular ion peak (M+H)+: 529/531 (Cl); found: molecular ion peak (M+H)+: 529/531 (Cl); Rf value: 0.55 (silica gel, dichloromethane/methanol (9:1)).

Provenance & Evidence