Ammonia methanol dichloromethane → HCID 57845718, compound

Participants

Reaction Steps

Prepared analogously to Example 2.3.f. from 150 mg (0.6 mmol) of (2-chloro-4-trifluoromethylphenyl)propynoic acid and 194 mg (0.66 mmol) of 1-[2-(4-amino-2-methoxyphenoxy)ethyl]piperidine-4-carboxylic acid amide. Yield: 310 mg (98% of theory); melting point: 150° C.; C25H25ClF3N3O4 (M=523.93); calc.: molecular ion peak (M+H)+: 524/526 (Cl); found: molecular ion peak (M+H)+: 524/526 (Cl); Rf value: 0.4 (silica gel, dichloromethane/methanol/ammonia (9:1:0.1)).

Provenance & Evidence