Cyclopropanemethanamine, N-propyl- → HCID 68819544, compound

HRID 735152Notes

Reaction equation

HRID 735152 reaction equation
Br[CH2:2][CH2:3][O:4][C:5]1[CH:10]=[CH:9][C:8]([N+:11]([O-:13])=[O:12])=[CH:7][C:6]=1[O:14][CH3:15].[CH:16]1([CH2:19][NH:20][CH2:21][CH2:22][CH3:23])[CH2:18][CH2:17]1>ClCCl.CO>[CH:16]1([CH2:19][N:20]([CH2:2][CH2:3][O:4][C:5]2[CH:10]=[CH:9][C:8]([N+:11]([O-:13])=[O:12])=[CH:7][C:6]=2[O:14][CH3:15])[CH2:21][CH2:22][CH3:23])[CH2:18][CH2:17]1

Participants

4

Reactant 2

HCID 117787Cyclopropanemethanamine, N-propyl-HCID 129372541-(2-Bromoethoxy)2-methoxy-4-nitrobenzene

Product 1

HCID 68819544HCID 68819544, compound

Reagents, catalysts & solvents 1

HCID 21226129Dichloromethane methanolSolvent

Procedure

Prepared analogously to Example 1.1.c. from 1 g (3.62 mmol) of 1-(2-bromoethoxy)-2-methoxy-4-nitrobenzene and 1.51 mL (10.57 mmol) of cyclopropylmethylpropylamine. Yield: 0.95 g (85% of theory); C16H24N2O4 (M=308.37); calc.: molecular ion peak (M+H)+: 309; found: molecular ion peak (M+H)+: 309; Rf value: 0.4 (silica gel, dichloromethane/methanol (9:1)).

Workup

  1. customPrepared analogously to Example 1.1.c

Sources & evidence

ORD record
ord-bd6262a6325b4badb3c153e306cac658
Source dataset
uspto-grants-2009_09
Patent number
US07592373B2

Reaction notes

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