Ammonia methanol dichloromethane → HCID 68819152, compound

HRID 735153Notes

Reaction equation

HRID 735153 reaction equation
[CH:1]1([CH2:4][N:5]([CH2:9][CH2:10][O:11][C:12]2[CH:17]=[CH:16][C:15]([N+:18]([O-])=O)=[CH:14][C:13]=2[O:21][CH3:22])[CH2:6][CH2:7][CH3:8])[CH2:3][CH2:2]1.ClCCl.CO.N>>[CH:1]1([CH2:4][N:5]([CH2:6][CH2:7][CH3:8])[CH2:9][CH2:10][O:11][C:12]2[CH:17]=[CH:16][C:15]([NH2:18])=[CH:14][C:13]=2[O:21][CH3:22])[CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 21584172Ammonia methanol dichloromethaneHCID 68819544HCID 68819544, compound

Product 1

HCID 68819152HCID 68819152, compound

Procedure

Prepared analogously to Example 3.1.b. from 950 mg (3.1 mmol) of cyclopropylmethyl-[2-(2-methoxy-4-nitrophenoxy)ethyl]propylamine. Yield: 0.74 g (86% of theory); C16H26N2O2 (M=278.39); calc.: molecular ion peak (M+H)+: 279; found: molecular ion peak (M+H)+: 279; Rf value: 0.4 (silica gel, dichloromethane/methanol/ammonia (9:1:0.1)).

Workup

  1. customPrepared analogously to Example 3.1.b

Sources & evidence

ORD record
ord-dc87d62865ab4d758fd3767ccc99e857
Source dataset
uspto-grants-2009_09
Patent number
US07592373B2

Reaction notes

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