HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Chloro-4-[2-(4-methylpiperidin-1-yl)ethyl]phenylamine → 3-(3-Bromobiphenyl-4-yl)propynoic acid-{3-chloro-4-[2-(4-methylpiperidin-1-yl)ethyl]phenyl}amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Chloro-4-[2-(4-methylpiperidin-1-yl)ethyl]phenylamine | HCID 59691670 | — |
| Reactant | (3-bromobiphenyl-4-yl)propynoic Acid | HCID 68818231 | — |
| Solvent | Dichloromethane methanol | HCID 21226129 | — |
| Product | 3-(3-Bromobiphenyl-4-yl)propynoic acid-{3-chloro-4-[2-(4-methylpiperidin-1-yl)ethyl]phenyl}amide | HCID 57845819 | — |
Reaction Steps
Prepared analogously to Example 2.3.f. from (3-bromobiphenyl-4-yl)propynoic acid and 3-chloro-4-[2-(4-methylpiperidin-1-yl)ethyl]phenylamine. Yield: 0.24 g (50% of theory); C29H28BrClN2O (M=535.90); calc.: molecular ion peak (M+H)+: 535/37/39; found: molecular ion peak (M+H)+: 535/37/39; Rf value: 0.48 (silica gel, dichloromethane/methanol (90:10)).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07592373B2 |
| Source dataset | uspto-grants-2009_09 |
| ORD ID | ord-b4bc4131b0bc4054b9f426436e5a9d06 |
| Source note | uspto-grants-2009_09 |