HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-[2-(4-Amino-2-chlorophenyl)ethyl]4-trifluoromethylpiperidin-4-ol → 3-(3-Bromobiphenyl-4-yl)propynoic acid-{3-chloro-4-[2-(4-hydroxy-4-trifluoromethylpiperidin-1-yl)ethyl]phenyl}amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-[2-(4-Amino-2-chlorophenyl)ethyl]4-trifluoromethylpiperidin-4-ol | HCID 68816043 | — |
| Reactant | (3-bromobiphenyl-4-yl)propynoic Acid | HCID 68818231 | — |
| Product | 3-(3-Bromobiphenyl-4-yl)propynoic acid-{3-chloro-4-[2-(4-hydroxy-4-trifluoromethylpiperidin-1-yl)ethyl]phenyl}amide | HCID 57845747 | — |
Reaction Steps
Prepared analogously to Example 2.3.f. from (3-bromobiphenyl-4-yl)propynoic acid and 1-[2-(4-amino-2-chlorophenyl)ethyl]4-trifluoromethylpiperidin-4-ol. Yield: 36 mg (10.5% of theory); C29H25BrClF3N2O2 (M=605.87); calc.: molecular ion peak (M+H)+: 605/07/09; found: molecular ion peak (M+H)+: 605/07/09.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07592373B2 |
| Source dataset | uspto-grants-2009_09 |
| ORD ID | ord-615db3aa2ba54a78aa58746b84119504 |
| Source note | uspto-grants-2009_09 |