HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Amino-4'-methoxybiphenyl → (E)-N-(4'-methoxybiphenyl-4-yl)-3-(4-pyrrolidin-1-ylmethylphenyl)acrylamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Amino-4'-methoxybiphenyl | HCID 2759564 | — |
| Reactant | Ammonia methanol dichloromethane | HCID 21584172 | — |
| Reactant | (E)-3-(4-pyrrolidin-1-ylmethylphenyl)acrylic Acid | HCID 68815843 | — |
| Product | (E)-N-(4'-methoxybiphenyl-4-yl)-3-(4-pyrrolidin-1-ylmethylphenyl)acrylamide | HCID 57845721 | — |
Reaction Steps
Prepared analogously to Example 3.1.e. from (E)-3-(4-pyrrolidin-1-ylmethylphenyl)acrylic acid and 4′-methoxybiphenyl-4-ylamine. Yield: 74 mg (15.4% of theory); melting point: 199° C.-200° C.; C27H28N2O2 (M=412.53); calc.: molecular ion peak (M+H)+: 413; found: molecular ion peak (M+H)+: 413; Rf value: 0.77 (silica gel, dichloromethane/methanol/ammonia (80:20:1)).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07592373B2 |
| Source dataset | uspto-grants-2009_09 |
| ORD ID | ord-ae53f41e392c44fcbd89ccdc30883030 |
| Source note | uspto-grants-2009_09 |