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38.81 mL (0.354 mmol) of trimethylorthoformate is added to a suspension of 25 g (0.141 mol) of (E)-3-(4-formylphenyl)acrylic acid in 350 mL of methanol and the mixture is refluxed for 48 hours. After cooling, the reaction mixture is filtered and the filtrate is evaporated down. The residue is taken up in 500 mL of dichloromethane and filtered through CELITE® filter aid. The filtrate is evaporated down to 150 mL and cooled to 0° C. The precipitate formed is filtered off, washed with dichloromethane/petroleum ether (1:1), and dried at 60° C. in the circulating air dryer. Yield: 12.05 g (31.5% of theory); C12H14O4 (M=222.24); calc.: molecular ion peak (M+H)+: 245; found: molecular ion peak (M+H)+: 245; Rf value: 0.6 (silica gel, petroleum ether/ethyl acetate (1:1)).

1. temperaturethe mixture is refluxed for 48 hours
2. temperatureAfter cooling
3. filtrationthe reaction mixture is filtered
4. customthe filtrate is evaporated down
5. filtrationfiltered through CELITE®
6. filtrationfilter aid
7. customThe filtrate is evaporated down to 150 mL
8. customThe precipitate formed
9. filtrationis filtered off
10. washwashed with dichloromethane/petroleum ether (1:1)
11. customdried at 60° C. in the circulating air dryer