HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Methylpiperidine → (E)-N-(4'-chlorobiphenyl-4-yl)-3-[4-(4-methylpiperidin-1-ylmethyl)phenyl]acrylamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Methylpiperidine | HCID 69381 | — |
| Reactant | (E)-N-(4'-chlorobiphenyl-4-yl)-3-(4-formylphenyl)acrylamide | HCID 86601892 | — |
| Solvent | Dichloromethane methanol | HCID 21226129 | — |
| Product | (E)-N-(4'-chlorobiphenyl-4-yl)-3-[4-(4-methylpiperidin-1-ylmethyl)phenyl]acrylamide | HCID 57845736 | — |
Reaction Steps
Prepared analogously to Example 4.30.c. from (E)-N-(4′-chlorobiphenyl-4-yl)-3-(4-formylphenyl)acrylamide and 4-methylpiperidine. Yield: 80 mg (21.7% of theory); melting point: 207° C.-208° C.; C28H29ClN2O (M=445.00); calc.: molecular ion peak (M+H)+: 445/447; found: molecular ion peak (M+H)+: 445/447; Rf value: 0.76 (silica gel, dichloromethane/methanol (10:1)).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07592373B2 |
| Source dataset | uspto-grants-2009_09 |
| ORD ID | ord-62d2ebf3141543b2bc8041849d058a66 |
| Source note | uspto-grants-2009_09 |