Cyclohexylamine → (E)-N-(4'-chlorobiphenyl-4-yl)-3-(4-cyclohexylaminomethylphenyl)acrylamide

Participants

Reaction Steps

0.082 mL (0.72 mmol) of cyclohexylamine is added to a suspension of 150 mg (0.39 mmol) of (E)-N-(4′-chlorobiphenyl-4-yl)-3-(4-chloromethylphenyl)acrylamide in 5 mL of THF and the mixture is refluxed for 18 hours. Then the reaction mixture is poured onto water and the precipitate formed is suction filtered. Further purification is carried out by column chromatography on silica gel (eluant: dichloromethane/methanol (95:5 to 50:50)). Yield: 70 mg (40% of theory); C28H29ClN2O (M=444.99); melting point: 247° C.-248° C.; Calc.: molecular ion peak (M+H)+: 445/447 (Cl); found: molecular ion peak (M+H)+: 445/447 (Cl).

Provenance & Evidence