tert-Butyl 4-(methylamino)piperidine-1-carboxylate → tert-butyl 4-({-[(E)-2-(4'-chlorobiphenyl-4-ylcarbamoyl)vinyl]benzyl}methylamino)piperidine-1-carboxylate

Participants

Reaction Conditions

Reaction Steps

0.5 g (2.34 mmol) of tert-butyl 4-methylaminopiperidine-1-carboxylate is added to a suspension of 300 mg (0.79 mmol) of (E)-N-(4′-chlorobiphenyl-4-yl)-3-(4-chloromethylphenyl)acrylamide in 5 mL of DMF and the mixture is stirred for 18 hours at 80° C. Then the reaction mixture is poured onto water and the precipitate formed is suction filtered. Further purification is carried out by stirring out from a little methanol. Yield: 200 mg (45% of theory); C33H38ClN3O3 (M=560.13); melting point: 168° C.-169° C.; calc.: molecular ion peak (M+H)+: 560/562 (Cl); found: molecular ion peak (M+H)+: 560/562 (Cl).

Provenance & Evidence