反应详情

A reaction mixture of 60 mg (0.14 mmol) of (E)-N-(4′-methoxybiphenyl-4-yl)-3-(4-pyrrolidin-1-ylmethylphenyl)acrylamide and 10 mg of Raney nickel in 30 mL of methanol is hydrogenated for 4 hours. The catalyst is filtered off and the filtrate is evaporated to dryness. Yield: 56 mg (93.2% of theory); melting point: 185° C.-188° C.; C27H30N2O2 (M=414.55); calc.: molecular ion peak (M+H)+: 415; found: molecular ion peak (M+H)+: 415; Rf value: 0.29 (silica gel, dichloromethane/methanol/ammonia (90:10:1)).

1. filtrationThe catalyst is filtered off
2. customthe filtrate is evaporated to dryness