Methyl iodide → HCID 68819707, compound

Participants

Reaction Steps

Tert-butyl 6-[(4-methylphenyl)sulfanyl]-1,3,4,5-tetrahydro-2H-pyrido[4,3-b]indole-2-carboxylate (22.6 mmol), potassium hydroxide (113 mmol), and iodomethane (226 mmol) were combined with dry DME (110 mL) and stirred at room temperature for 10 hours. The reaction was then filtered and the residue washed with chloroform. The filtrate was concentrated under reduced pressure to give tert-butyl 5-methyl-6-[(4-methylphenyl)sulfanyl]-1,3,4,5,-tetrahydro-2H-pyrido[4,3-b]indole-2-carboxylate (95%).

Provenance & Evidence