Phenol → 1-Indanone

Participants

Reaction Steps

To a CH2Cl2 (2 mL) solution of the phenol from Example 31 (10.5 mg, 0.03 mmol) was added triethylamine (21 μL, 5 eq), DMAP (0.5 M dichloromethane solution, 6 μL, 0.1 eq) and methyl chloroformate (4.6 μL, 2 eq). The mixture was stirred at room temperature for 1.5 h, concentrated and purified by reverse-phase HPLC (70 to 100% solvent B) to give Example 32 (12 mg, 99%). MS Found: (M+H)+=409.

Provenance & Evidence