Triethylamine → HCID 76582005, compound

Participants

Reaction Steps

A mixture of Example 36 (11.3 mg, 0.032 mmol), Cu(OAc)2 (8.9 mg, 1.5 eq), phenylboronic acid (11.3 mg, 2.9 mmol), triethylamine (22.6 μL, 5 eq) and powdered 4 Å molecular sieve (33.7 mg) in CH2Cl2 (2.5 mL) was stirred at room temperature for 16 h while open to the atmosphere. After filtration to remove the molecular sieve, the filtrate was concentrated and purified by reverse-phase HPLC (80-100% solvent B gradient) to give Example 155. (4.9 mg, 36%). MS Found: (M+H)+=427.

Provenance & Evidence