3-Methylindene-2-carboxylic acid → HCID 57847626, compound

HRID 735294Notes

Reaction equation

HRID 735294 reaction equation
[CH3:1][C:2]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH2:4][C:3]=1[C:11]([OH:13])=O.[NH2:14][C:15]1[S:16][CH:17]=[C:18]([CH2:20][C:21]2[CH:26]=[CH:25][C:24]([C:27]3[CH:32]=[CH:31][N:30]=[CH:29][CH:28]=3)=[CH:23][CH:22]=2)[N:19]=1>>[CH3:1][C:2]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH2:4][C:3]=1[C:11]([NH:14][C:15]1[S:16][CH:17]=[C:18]([CH2:20][C:21]2[CH:22]=[CH:23][C:24]([C:27]3[CH:32]=[CH:31][N:30]=[CH:29][CH:28]=3)=[CH:25][CH:26]=2)[N:19]=1)=[O:13]

Participants

3

Reactant 2

HCID 1186163-Methylindene-2-carboxylic acidHCID 589307704-[[4-(4-Pyridinyl)phenyl]methyl]-2-thiazolamine

Product 1

HCID 57847626HCID 57847626, compound

Procedure

Using a procedure similar to the synthesis of Example 2, 3-methyl-1H-indene-2-carboxylic acid was reacted with 2-amino-4-(4-(pyridin-4-yl)benzyl)thiazole to give Example 170. MS Found: (M+H)+=424.

Workup

  1. customto give Example 170

Sources & evidence

ORD record
ord-4f71d87716204e74bb01ca712758411f
Source dataset
uspto-grants-2009_09
Patent number
US07592461B2

Reaction notes

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