4-Fluorophenylboronic acid → HCID 68900236, compound

HRID 735310Notes

Reaction equation

HRID 735310 reaction equation
Br[C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[CH:8]=[C:7]([S:12]([C:15]1[CH:22]=[CH:21][CH:20]=[CH:19][C:16]=1[C:17]#[N:18])(=[O:14])=[O:13])[CH:6]=[CH:5]2.[F:23][C:24]1[CH:29]=[CH:28][C:27](B(O)O)=[CH:26][CH:25]=1>>[F:23][C:24]1[CH:29]=[CH:28][C:27]([C:2]2[CH:3]=[C:4]3[C:9](=[CH:10][CH:11]=2)[CH:8]=[C:7]([S:12]([C:15]2[CH:22]=[CH:21][CH:20]=[CH:19][C:16]=2[C:17]#[N:18])(=[O:14])=[O:13])[CH:6]=[CH:5]3)=[CH:26][CH:25]=1

Participants

3

Reactant 2

HCID 2856454-Fluorophenylboronic acidHCID 68900079HCID 68900079, compound

Product 1

HCID 68900236HCID 68900236, compound

Procedure

Prepared from 2-[(6-bromo-2-naphthyl)sulfonyl]benzonitrile (Step 3) and 4-fluorobenzeneboronic acid according to the method of Example 2 Step 1. 1H NMR (500 MHz, CDCl3) δ 8.80 (1H, s), 8.42 (1H, d, J=7.9 Hz), 8.11 (1H, d, J=8.6 Hz), 8.00 (2H, t, J=9.0 Hz), 7.93 (1H, dd, J=1.7, 8.7 Hz), 7.85-7.79 (3H, m), 7.70-7.64 (3H, m), 7.19 (2H, t, J=8.6 Hz).

Sources & evidence

ORD record
ord-cc7ab349c8ac47a3a9b61aa1d3c188a0
Source dataset
uspto-grants-2009_09
Patent number
US07592456B2

Reaction notes

Loading…