Triphenylphosphine → HCID 68899028, compound

Participants

Reaction Conditions

Reaction Steps

1-(2,4-Difluorophenyl)prop-2-en-1-ol (Step 3, 260 mg, 1.41 mmol), [2-iodo-4-(phenylsulfonyl)phenyl]amine (Step 2, 359 mg, 1 mmol), palladium acetate (22 mg, 0.1 mmol), sodium hydrogencarbonate (162 mg, 3 mmol) and triphenylphosphine (26 mg, 0.1 mmol) were combined in hexamethylphosphoramide (5 mL) and heated to 140° C. for 16 hours. The reaction mixture was diluted with water and extracted with ethyl acetate. The combined organic layers were washed with brine (x5), dried over MgSO4 and evaporated. The residue was purified by preparative HPLC to give the title compound (39 mg). 1H NMR (500 MHz, CDCl3) δ 8.59 (1H, d), 8.32 (1H, d), 8.21-8.14 (2H, m), 8.10 (1H, dd, J=2.1, 8.9 Hz), 8.03-7.98 (3H, m), 7.61-7.52 (3H, m), 7.09-7.05 (1H, m), 6.99-6.94 (1H, m).

Provenance & Evidence