Cesium carbonate → HCID 68900138, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 6-(2-cyano-4-fluorophenyl)-2-naphthyl trifluoromethanesulfonate (0.65 g, 1.65 mmol), sodium benzene sulfinate (0.33 g, 1.97 mmol), cesium carbonate (0.81 g, 2.48 mmol), tris(dibenzylideneacetone)dipalladium(0) (38 mg, 0.04 mmol), 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene (49 mg, 0.08 mmol) and tetrabutylammonium chloride (0.55 g, 1.98 mmol) in toluene (15 mL) was heated at 120° C. under nitrogen for 4 hours. It was allowed to cool, poured into water (150 mL) and extracted with ethyl acetate (2×100 mL). These extracts were washed with water and brine then dried (MgSO4), filtered and solvent removed in vacuo. Purification by flash column chromatography eluting with 20% ethyl acetate/isohexane then 40% ethyl acetate/isohexane gave 5-fluoro-2-[6-(phenylsulfonyl)-2-naphthyl]benzonitrile (150 mg, 23%). 1H NMR (500 MHz, d6-DMSO) δ 8.82 (1H, s), 8.38 (1H, d, J=8.5 Hz), 8.26 (1H, s), 8.23 (1H, d, J=8.7 Hz), 8.05-8.03 (3H, m), 7.98 (1H, d, J=8.6 Hz), 7.88 (1H, d, J=8.5 Hz), 7.81-7.63 (5H, m); m/z (ES+) 388 [MH+].

Provenance & Evidence