Dichloromethane → [3-(2-benzyl-7-trifluoromethyl-2H-indazol-3-yl)-phenyl]-methanol

Participants

Reaction Steps

To a solution of 116 mg (0.305 mmol) of 3-[2-benzyl-7-(trifluoromethyl)-2H-indazol-3-yl]benzaldehyde (compound of Formula (I)), prepared in a same way as Example 1, in 2 ml of methanol, 23 mg (0.71 mmol) of NaBH4 was added at 0° C. The reaction mixture was stirred at this temperature for 1 hr. Saturated NH4Cl-solution and dichloromethane were added, and the phases were separated. The product was obtained after flash chromatographic purification using dichloromethane as eluant. Yield: 111 mg.

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