Water → HCID 11660224, compound

Participants

Reaction Conditions

Reaction Steps

3-Chloro-2-phenyl-7-trifluoromethyl-2H-indazole (21 mg, 0.07 mmol, compound of formula (XI)) was dissolved in 0.5 ml of DMSO and 100 μl of piperidine (1 mmol) were added. The reaction mixture was stirred overnight at 110° C. After cooling to room temperature, 10 volumes of water were added. The supernatant was removed and the residue was purified by column chromatography on silica (n-heptane/ethyl acetate, 50:50, as eluent) to provide the title compound as a white solid (9 mg, 37%).

Provenance & Evidence