HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrazine hydrate (1:1) → 3-(2,4-dimethoxyphenyl)-7-fluoro-1H-indazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrazine hydrate (1:1) | HCID 24654 | — |
| Reactant | (2,3-Difluorophenyl)(2,4-dimethoxyphenyl)methanone | HCID 67021364 | — |
| Catalyst | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| Product | 3-(2,4-dimethoxyphenyl)-7-fluoro-1H-indazole | HCID 178489145 | 105.1% |
Reaction Steps
Prepared as in Example 104 from (2,4-dimethoxyphenyl)[2,3-difluorophenyl]methanone (1.60 g, 5.8 mmol), hydrazine hydrate (1.79 mL, 5702 mmol) and DMAP (0.632 g, 57.5 mmol) to give the product (1.66 g) as a yellow solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07592363B2 |
| Source dataset | uspto-grants-2009_09 |
| ORD ID | ord-e11e8342b9bf4d1a9353532f3fd8feaa |
| Source note | uspto-grants-2009_09 |