HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 735440Generated: October 30, 2026
Hydrochloric Acid → 2-(2,4-Dimethylbenzyl)-3-(4-fluorophenyl)-2H-indazole-7-carboxylic acid
https://huagongshe.com/reaction/735440
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | methyl 2-(2,4-dimethylbenzyl)-3-(4-fluorophenyl)-2H-indazole-7-carboxylate | HCID 11696743 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 2-(2,4-Dimethylbenzyl)-3-(4-fluorophenyl)-2H-indazole-7-carboxylic acid | HCID 67021280 | 0.5% |
Reaction Steps
A solution of methyl 2-(2,4-dimethylbenzyl)-3-(4-fluorophenyl)-2H-indazole-7-carboxylate (0.195 g, 0.5 mmol) in 5 mL methanol was treated with 1 mL of 1N NaOH and stirred at 50° C. for 1 hour. The solution was neutralized with dilute HCl and partitioned with ethyl acetate and H2O. The organic phase was dried (Na2SO4) and concentrated in vacuo to give 0.95 mg of the title compound as a yellow solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07592363B2 |
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| Source dataset | uspto-grants-2009_09 |
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| ORD ID | ord-78731feab545482c901a9ad2c7579301 |
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| Source note | uspto-grants-2009_09 |
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