Tetrahydrofuran → HCID 86603019, compound

Participants

Reaction Steps

A solution of methyl [4-fluoro-2-({3-[2-(2,4,6-trifluorobenzyl)-7-(trifluoromethyl)-2H-indazol-3-yl]phenyl}ethynyl)phenyl]carbamate (0.07 g, 0.12 mmol) and tetrabutylammonium fluoride (0.24 mL, 0.24 mmol, 1M solution in THF) in 2 mL THF was heated at 60° C. for 21 hours. The reaction mixture was concentrated in vacuo and the residue purified by normal phase HPLC (silica, hexane-EtOAC, 19:1) to give 0.045 g of product as a white solid.

Provenance & Evidence