Hydroxyamine hydrochloride → HCID 86603024, compound

Participants

Reaction Steps

Then a solution of N-(diphenylmethylene)-N-{3-[2-(2,4,6-trifluorobenzyl)-7-(trifluoromethyl)-2H-indazol-3-yl]phenyl}amine (0.77 g, 1.31 mmol) in methanol (10 mL) was treated with sodium acetate (0.25 g, 3 mmol) and hydroxylamine hydrochloride (0.15 g, 2.2 mmol), and stirred at room temperature for 2 hours. The methanol was evaporated and the residue slurried in ether, the inorganic solid filtered off, and the ether stripped to afford crude product, which was purified by flash chromatography (silica 60, 10% hexane/ethyl acetate) to afford the title compound (0.28 g, 50%).

Provenance & Evidence