Benzoyl chloride → HCID 86603026, compound

Participants

Reaction Steps

Combined in a vial were 3-(4-piperazin-1-ylphenyl)-2-(2,4,6-trifluorobenzyl)-7-(trifluoromethyl)-2H-indazole (0.10 g, 0.2 mmol), benzoyl chloride (0.030 g, 0.22 mmol), and diisopropylethylamine (0.2 mL) and THF (2 mL), which were stirred overnight at room temperature. Then the reaction mixture was diluted with ethyl acetate and water, and the organics washed with water and brine, then dried over magnesium sulfate. The crude product was purified by flash chromatography (silica 60, 5% EtOAc/CH2Cl2) to provide the title compound (0.06 g, 50%).

Provenance & Evidence