HuagongsheHuagongshe Chemistry Print Report · For research reference only
Lithium Hydroxide → HCID 67021164, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Lithium Hydroxide | HCID 3939 | — |
| Reactant | Cesium carbonate | HCID 10796 | — |
| Reactant | Benzeneacetic acid, alpha-bromo-, methyl ester | HCID 137806 | — |
| Reactant | HCID 67021271 | HCID 67021271 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 67021164 | HCID 67021164 | — |
Reaction Steps
3-[2-(4-Chloro-2-fluoro-benzyl)-7-trifluoromethyl-2H-indazol-3-yl]-phenol (25 mg, 1 eq) was treated with bromo-phenyl-acetic acid methyl ester (41 mg, 3 eq) and cesium carbonate (95 mg, 5 eq) in dichloromethane (2 mL) until the reaction mixture was completed as judged by TLC. Water was added followed by extraction with dichloromethane. Subsequently, the ester was hydrolyzed in aq. LiOH (1M, 15 eq)/THF 1:1. Purification by flash chromatography, eluent: 2-5% methanol in dichloromethane, afforded the title compound in 55% yleld.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07592363B2 |
| Source dataset | uspto-grants-2009_09 |
| ORD ID | ord-e5460cd6a1dd494a94534dc3b5c0b0e3 |
| Source note | uspto-grants-2009_09 |