4-Chloro-3-nitropyridine → HCID 131729685, compound

HRID 73548Notes

Reaction equation

HRID 73548 reaction equation
[Si:1]([O:8][CH2:9][C@H:10]1[CH2:15][NH:14][CH2:13][C@@H:12]([NH:16][C:17](=[O:23])[O:18][C:19]([CH3:22])([CH3:21])[CH3:20])[CH2:11]1)([C:4]([CH3:7])([CH3:6])[CH3:5])([CH3:3])[CH3:2].Cl[C:25]1[CH:30]=[CH:29][N:28]=[CH:27][C:26]=1[N+:31]([O-:33])=[O:32]>>[Si:1]([O:8][CH2:9][C@H:10]1[CH2:15][N:14]([C:25]2[CH:30]=[CH:29][N:28]=[CH:27][C:26]=2[N+:31]([O-:33])=[O:32])[CH2:13][C@@H:12]([NH:16][C:17](=[O:23])[O:18][C:19]([CH3:22])([CH3:21])[CH3:20])[CH2:11]1)([C:4]([CH3:7])([CH3:6])[CH3:5])([CH3:3])[CH3:2]

Participants

3

Reactant 2

HCID 27357814-Chloro-3-nitropyridineHCID 131729686HCID 131729686, compound

Product 1

HCID 131729685HCID 131729685, compound

Procedure

Method 1 was followed using cis (+/−)-tert-butyl 5-((tert-butyl-dimethylsilyloxy)methyl)piperidin-3-ylcarbamate and 4-chloro-3-nitropyridine yielding cis (+/−)-tert-butyl 5-((tert-butyldimethylsilyloxy)methyl)-1-(3-nitropyridin-4-yl)-piperidin-3-ylcarbamate. LCMS (m/z): 467.0 (MH+); LC Rt=4.02 min.

Sources & evidence

ORD record
ord-4ef90d645da74912b39c53eee5494076
Source dataset
uspto-grants-2014_09
Patent number
US08829193B2

Reaction notes

Loading…