Acetone → HCID 86603031, compound

Participants

Reaction Steps

2-benzyl-3-[4-(3-[1,3]dioxolan-2-ylmethyl-phenoxy)-phenyl]-7-trifluoromethyl-2H-indazole (14 mg, 0.0264 mmol) was treated with 6.6 mg PPTS in 1.5 ml acetone under reflux for 2 hrs. The reaction mixture was extracted with NaHCO3 and CH2Cl2. The combined organic phases were dried, evaporated and the crude material was purified on a chromatotron using a gradient changing from 1:99 (EtOAc/heptane) to 3:7 (EtOAc/heptane) to afford 5 mg of analytically pure product.

Provenance & Evidence