Aluminium lithium hydride → HCID 68817938, compound

Participants

Reaction Steps

This compound was prepared from methyl 3-{4-[2-benzyl-7-(trifluoromethyl)-2H-indazol-3-yl]phenoxy}benzoate (Example 912; 30 mg, 0.060 mmol), which was dissolved in 1.5 ml diethylether and treated with LiAlH4. The reaction mixture was stirred at room temperature overnight. The reaction mixture was quenched with water and stirred for 15 minutes. The slurry was filtered and the product extracted with Et2O/NH4Cl (aq, sat). After evaporation of the solvents, the crude material was purified by HPLC using a gradient with an acidic mobile phase on an ACE-C8 column to afford 19.6 mg of analytically pure product.

Provenance & Evidence