反应详情

2A (343 mg, 1.24 mmol) was added to a mixture of diethyl ether (10 mL) and NaOH (2 mL, 2 N). The reaction mixture was stirred at rt for 10 min. The ether layer was separated and then treated with an additional portion of NaOH for 5 min. The combined aqueous layers were washed with diethyl ether (2×) and acidified to pH 4 with hydrochloric acid (6 N). The resulting solid precipitate was collected by filtration to afford 2B contaminated with 2A (212 mg, 1:1 2B/2A, 43% yield based on content of 2B) as a beige solid.

1. customThe ether layer was separated
2. additiontreated with an additional portion of NaOH for 5 min
3. washThe combined aqueous layers were washed with diethyl ether (2×)
4. filtrationThe resulting solid precipitate was collected by filtration