HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Hydroxide → 4-(4-(3-Cyano-4-(isopropylsulfonyl)phenylamino)-4-oxobutyl)phenylboronic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 4-(4-Boronophenyl)butanoic acid | HCID 57842598 | — |
| Reactant | N-(3-Cyano-4-(isopropylsulfonyl)phenyl)-4-(4-(5,5-dimethyl-1,3,2-dioxaborinan-2-yl)phenyl)butanamide | HCID 57842872 | — |
| Product | 4-(4-(3-Cyano-4-(isopropylsulfonyl)phenylamino)-4-oxobutyl)phenylboronic acid | HCID 57842605 | 95.1% |
Reaction Steps
Using a procedure analogous to that used to prepare 2B, 9D (625 mg, 1.29 mmol) was reacted with NaOH to give 9E (508 mg, 95%) as a brown foam. MS (ESI) m/z 413.2 (M−H)−.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07592331B2 |
| Source dataset | uspto-grants-2009_09 |
| ORD ID | ord-fcaa447d270c48a19f837e8f95a9b8f6 |
| Source note | uspto-grants-2009_09 |