HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-(4-Bromophenyl)butanoic acid → tert-Butyl 5-(4-(4-bromophenyl)butanamido)-2-(isopropylthio)benzyl(methyl)carbamate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-(4-Bromophenyl)butanoic acid | HCID 57472 | — |
| Reactant | tert-Butyl-(5-amino-2-(isopropylthio)benzyl)(methyl)carbamate | HCID 57842879 | — |
| Reactant | tert-Butyl 5-(4-(4-bromophenyl)butanamido)-2-(ethylthio)benzyl(methyl)carbamate | HCID 57956370 | — |
| Product | tert-Butyl 5-(4-(4-bromophenyl)butanamido)-2-(isopropylthio)benzyl(methyl)carbamate | HCID 57842807 | 89% |
Reaction Steps
Using a procedure analogous to that used for preparation of 17B, 16E (0.418 g, 1.35 mmol) was reacted with 4-bromophenylbutanoic acid (0.340 g, 1.40 mmol) to give 18A (0.642 g, 89%) as a white solid. MS (ESI) m/z 537.0 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07592331B2 |
| Source dataset | uspto-grants-2009_09 |
| ORD ID | ord-b9b7dfa49d1542adac6d6142db2daf41 |
| Source note | uspto-grants-2009_09 |