4-Bromo-2-ethyl-1-iodobenzene → Benzyl 4-(4-bromo-2-ethylphenyl)butanoate

참여 물질

반응 단계

Using a procedure analogous to that used to prepare 8A, benzyl but-3-enoate (3.63 g, 0.020 mmol, reference for preparation: Cardillo, G.; De Simone, A.; Mingardi, A.; Tomasini, C. Synlett 1995, 11, 1131-2) was reacted with 4-bromo-2-ethyl-iodobenzene (6.23 g, 0.020 mmol) to give 21A (1.5 g, 21%). 1H NMR (400 MHz, CDCl3) δ ppm 1.18 (t, J=7.69 Hz, 3 H) 1.84-1.94 (m, 2 H) 2.41 (t, J=7.25 Hz, 2 H) 2.55-2.62 (m, 4 H) 5.12 (s, 1 H) 6.96 (d, J=7.91 Hz, 1 H) 7.22 (dd, J=7.91, 2.20 Hz, 1 H) 7.29 (d, J=2.20 Hz, 1 H) 7.30-7.40 (m, 5 H).

출처 및 근거