HuagongsheHuagongshe Chemistry Print Report · For research reference only
Bis(neopentyl glycolato)diboron → 4-(4-(3-((tert-Butoxycarbonyl(methyl)amino)methyl)-4-(isopropylsulfonyl)phenylamino)-4-oxobutyl)-3-ethylphenylboronic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Bis(neopentyl glycolato)diboron | HCID 2734316 | — |
| Reactant | 4-(4-(3-Cyano-4-(ethylsulfonyl)phenylamino)-4-oxobutyl)phenylboronic acid | HCID 57842684 | — |
| Reactant | tert-Butyl 5-(4-(4-bromo-2-ethylphenyl)butanamido)-2-(isopropylsulfonyl)benzyl(methyl)carbamate | HCID 57842767 | — |
| Product | 4-(4-(3-((tert-Butoxycarbonyl(methyl)amino)methyl)-4-(isopropylsulfonyl)phenylamino)-4-oxobutyl)-3-ethylphenylboronic acid | HCID 57842801 | 67% |
Reaction Steps
Using a procedure analogous to that described for the preparation of 6D, 21C (0.513 g, 0.86 mmol) was coupled to 5,5,5′,5′-tetramethyl-[2,2′]bi[[1,3,2]dioxaborinanyl] (0.215 g, 0.952 mmol) and hydrolyzed to give boronic acid 21D (0.278 g, 67%). MS (ESI) m/z 561.48 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07592331B2 |
| Source dataset | uspto-grants-2009_09 |
| ORD ID | ord-df070f710c7448e380762586cf709e84 |
| Source note | uspto-grants-2009_09 |