HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(4-(3-Cyano-4-(ethylsulfonyl)phenylamino)-4-oxobutyl)phenylboronic acid → 4-(2-(3-(3-Cyanophenyl)-1-methylureido)ethyl)phenylboronic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(4-(3-Cyano-4-(ethylsulfonyl)phenylamino)-4-oxobutyl)phenylboronic acid | HCID 57842684 | — |
| Reactant | 1-(4-Bromophenethyl)-3-(3-cyanophenyl)-1-methylurea | HCID 57842819 | — |
| Product | 4-(2-(3-(3-Cyanophenyl)-1-methylureido)ethyl)phenylboronic acid | HCID 57842610 | 91% |
Reaction Steps
Using a procedure analogous to that used to prepare 6D, 23C (200 mg, 0.70 mmol) was reacted with 5,5′,5′-tetramethyl-[2,2′]bi[[1,3,2]dioxaborinanyl] to give 23D (165 mg, 91%) as a yellow oil. MS (ESI) m/z 324.03 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07592331B2 |
| Source dataset | uspto-grants-2009_09 |
| ORD ID | ord-6f563273d4994cbb87e004ccaa213958 |
| Source note | uspto-grants-2009_09 |