2-(1-(Bis(tert-butoxycarbonyl)amino)isoquinolin-6-ylamino)-2-(4-(2-(3-cyano-4-(ethylsulfonyl)phenylcarbamoyloxy)ethyl)phenyl)acetic acid → 2-(4-(2-(3-(Aminomethyl)-4-(ethylsulfonyl)phenylcarbamoyloxy)ethyl)phenyl)-2-(1-(bis(tert-butoxycarbonyl)amino)isoquinolin-6-ylamino)acetic acid

Participants

Role	Name	HCID	Charge
Reactant	2-(1-(Bis(tert-butoxycarbonyl)amino)isoquinolin-6-ylamino)-2-(4-(2-(3-cyano-4-(ethylsulfonyl)phenylcarbamoyloxy)ethyl)phenyl)acetic acid	HCID 57842601	—
Reactant	HCID 57842775	HCID 57842775	—
Product	2-(4-(2-(3-(Aminomethyl)-4-(ethylsulfonyl)phenylcarbamoyloxy)ethyl)phenyl)-2-(1-(bis(tert-butoxycarbonyl)amino)isoquinolin-6-ylamino)acetic acid	HCID 57842738	165.3%

Reaction Steps

Using a procedure analogous to that used to prepare 25E, 26C (374 mg, 0.21 mmol) was hydrogenated for 15 h to give 26D (270 mg, 72%) as a yellow glass. MS (ESI) m/z 777.93 (M+H)+.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07592331B2
Source dataset	uspto-grants-2009_09
ORD ID	ord-aeea1fffd193457d98cee688b5ce4bab
Source note	uspto-grants-2009_09