HuagongsheHuagongshe Chemistry Print Report · For research reference only
Glyoxylic acid, monohydrate → 2-(1-(Bis(tert-butoxycarbonyl)amino)isoquinolin-6-ylamino)-2-(4-(2-(3-cyano-4-(ethylsulfonyl)phenylcarbamoyloxy)ethyl)-3-methylphenyl)acetic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Glyoxylic acid, monohydrate | HCID 15620607 | — |
| Reactant | 4-(2-(3-Cyano-4-(ethylsulfonyl)phenylcarbamoyloxy)ethyl)-3-methylphenylboronic acid | HCID 57842638 | — |
| Reactant | tert-butyl N-(6-aminoisoquinolin-1-yl)-N-[(tert-butoxy)carbonyl]carbamate | HCID 58717298 | — |
| Product | 2-(1-(Bis(tert-butoxycarbonyl)amino)isoquinolin-6-ylamino)-2-(4-(2-(3-cyano-4-(ethylsulfonyl)phenylcarbamoyloxy)ethyl)-3-methylphenyl)acetic acid | HCID 57842626 | 44% |
Reaction Steps
Using a procedure analogous to that used to prepare 2D, 31B (468 mg, 1.1 mmol) was reacted with Intermediate 1 and glyoxylic acid monohydrate to afford 31C (419 mg, 44%) as a pale yellow solid. MS (ESI) m/z 788.07 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07592331B2 |
| Source dataset | uspto-grants-2009_09 |
| ORD ID | ord-52f4d8f180c549e0a4a67fdb71654b00 |
| Source note | uspto-grants-2009_09 |