Benzyl 3-(diethoxyphosphorylamino)-4-methylpiperidine-1-carboxylate → HCID 67045186, compound

HRID 73560Notes

Reaction equation

HRID 73560 reaction equation
[CH2:1]([O:3][P:4]([NH:9][CH:10]1[CH:15]([CH3:16])[CH2:14][CH2:13][N:12](C(OCC2C=CC=CC=2)=O)[CH2:11]1)([O:6][CH2:7][CH3:8])=[O:5])[CH3:2]>CO.[Pd]>[CH3:16][CH:15]1[CH2:14][CH2:13][NH:12][CH2:11][CH:10]1[NH:9][P:4](=[O:5])([O:6][CH2:7][CH3:8])[O:3][CH2:1][CH3:2]

Participants

4

Reactant 1

HCID 60205257Benzyl 3-(diethoxyphosphorylamino)-4-methylpiperidine-1-carboxylate

Product 1

HCID 67045186HCID 67045186, compoundYield 83%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

To a solution of benzyl 3-(diethoxyphosphorylamino)-4-methylpiperidine-1-carboxylate (1.0 equiv.) in degassed MeOH was added Pd/C (10% by weight) and the reaction was stirred under a hydrogen atmosphere for 1 h. The solution was filtered, then concentrated to yield diethyl 4-methylpiperidin-3-ylphosphoramidate in 83% yield. LCMS (m/z): 251.1 (MH+).

Workup

  1. filtrationThe solution was filtered
  2. concentrationconcentrated

Sources & evidence

ORD record
ord-1d172d55f66444b3a625cda49fbdbffc
Source dataset
uspto-grants-2014_09
Patent number
US08829193B2

Reaction notes

Loading…