3-Aminobenzamide → HCID 57842676, compound

HRID 735608Notes

Reaction equation

HRID 735608 reaction equation
[C:1]([C:3]1[CH:4]=[C:5]([NH:9][C:10]([O:12][CH2:13][CH2:14][C:15]2[C:20]([CH2:21][CH3:22])=[CH:19][C:18](B(O)O)=[CH:17][C:16]=2[CH2:26][CH3:27])=[O:11])[CH:6]=[CH:7][CH:8]=1)#[N:2].[NH2:28][C:29]1[CH:30]=[C:31]([CH:35]=[CH:36][CH:37]=1)[C:32]([NH2:34])=[O:33].O.[C:39]([OH:43])(=[O:42])[CH:40]=O>>[C:32]([C:31]1[CH:30]=[C:29]([NH:28][CH:40]([C:18]2[CH:19]=[C:20]([CH2:21][CH3:22])[C:15]([CH2:14][CH2:13][O:12][C:10](=[O:11])[NH:9][C:5]3[CH:6]=[CH:7][CH:8]=[C:3]([C:1]#[N:2])[CH:4]=3)=[C:16]([CH2:26][CH3:27])[CH:17]=2)[C:39]([OH:43])=[O:42])[CH:37]=[CH:36][CH:35]=1)(=[O:33])[NH2:34]

Participants

4

Reactant 3

HCID 16453-AminobenzamideHCID 15620607Glyoxylic acid, monohydrateHCID 57842869HCID 57842869, compound

Product 1

HCID 57842676HCID 57842676, compoundYield 70%

Procedure

Using a procedure analogous to that used to prepare 2D, 37E (80 mg, 0.22 mmol) was reacted with 3-aminobenzamide and glyoxylic acid monohydrate to afford 37F (81 mg, 70%) as a yellow oil. MS (ESI) m/z 515.21 (M+H)+.

Sources & evidence

ORD record
ord-da891ffbda2942fab4b99bf51dbe21d8
Source dataset
uspto-grants-2009_09
Patent number
US07592331B2

Reaction notes

Loading…