HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thionyl Chloride → (r)-Ethyl 3-amino-3-(3-nitrophenyl)propanoate hydrochloride salt
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | (s)-3-Amino-3-(3-nitrophenyl)propionic acid | HCID 706689 | — |
| Reactant | (s)-Ethyl 3-amino-3-(3-nitrophenyl)propanoate hydrochloride salt | HCID 86614935 | — |
| Product | (r)-Ethyl 3-amino-3-(3-nitrophenyl)propanoate hydrochloride salt | HCID 86614936 | 99% |
Reaction Steps
Using a procedure analogous to that used to prepare 34A, (S)-3-amino-3-(3-nitrophenyl)propanoic acid (2.1 g, 10 mmol) was reacted with thionyl chloride to 10 afford 39A (2.75 g, 99%) as a white solid. MS (ESI) m/z 239.08 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07592331B2 |
| Source dataset | uspto-grants-2009_09 |
| ORD ID | ord-6ec1eb1c0c554cf7884ae5f25c3215da |
| Source note | uspto-grants-2009_09 |