(R)-ethyl 3-(3-aminophenyl)-3-(benzyloxycarbonylamino)propanoate → (R)-ethyl 3-(benzyloxycarbonylamino)-3-(3-((4-bromo-2-methylphenethoxy)carbonylamino)phenyl)propanoate

Participants

Role	Name	HCID	Charge
Reactant	(R)-ethyl 3-(3-aminophenyl)-3-(benzyloxycarbonylamino)propanoate	HCID 57842606	—
Reactant	HCID 57842704	HCID 57842704	—
Reactant	2-(4-Bromo-2-methylphenyl)ethanol	HCID 57842852	—
Product	(R)-ethyl 3-(benzyloxycarbonylamino)-3-(3-((4-bromo-2-methylphenethoxy)carbonylamino)phenyl)propanoate	HCID 57842714	56%

Reaction Steps

Using a procedure analogous to that used to prepare 34D, 39C (1.12 g, 3.3 mmol) was reacted with 30B (700 mg, 3.3 mmol) to afford 39D (1.07 g, 56%) as a colorless oil. MS (ESI) m/z 583.13/585.13 (M+H)+.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07592331B2
Source dataset	uspto-grants-2009_09
ORD ID	ord-21537bb8dfdf4c2e86c9528821938f5e
Source note	uspto-grants-2009_09